CYTOMEL Oral 25 mcg tablet(Liothyronine sodium)

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CYTOMEL 25 mcg (Liothyronine sodium) may be used for replacement or substitution of diminished or absent thyroid function resulting from primary causes including functional deficiency, primary atrophy, or partial or complete absence of the gland or the effects of surgery, radiation, or antithyroid agents; however, levothyroxine sodium is generally preferred for long-term therapy in these conditions. Liothyronine sodium also may be used for replacement or supplemental therapy in patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism. Therapy must be maintained continuously to control the symptoms of hypothyroidism. Because liothyronine sodium has a rapid onset and short duration of action, some clinicians prefer its use to levothyroxine sodium when a rapid effect or rapidly reversible effect is desired (e.g., diagnostic procedures requiring short-term thyrotropin suppression, myxedema coma); however, the fact that liothyronine produces wide swings in serum triiodothyronine concentrations and the possibility of more pronounced adverse cardiovascular effects generally make the drug unsatisfactory for long-term use. Liothyronine sodium may be useful when absorption of levothyroxine sodium is questionable or impairment of peripheral conversion of thyroxine to triiodothyronine is suspected.

Liothyronine sodium is used principally in the T3 suppression test to differentiate suspected hyperthyroidism from euthyroidism in patients with I 131 thyroid uptake values in the borderline-high range.